Usefulness of Hyperemic Microvascular Resistance Index as a Predictor of Clinical Outcomes in Patients with ST-Segment Elevation Myocardial Infarction
Korean Circulation Journal
;
: 194-201, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-19608
ABSTRACT
BACKGROUND AND OBJECTIVES:
Microvascular function is a useful predictor of left ventricular functional changes in patients with ST-segment elevation myocardial infarction (STEMI). We evaluated the usefulness of the hyperemic microvascular resistance index (hMVRI) for predicting long-term major adverse cardiovascular events (MACEs) in patients with STEMI assessed immediately after primary percutaneous coronary intervention (PCI). SUBJECTS ANDMETHODS:
hMVRI were evaluated in 145 patients with first acute STEMI treated with primary PCI using an intracoronary Doppler wire. hMVRI was defined as the ratio of mean aortic pressure over hyperemic averaged peak velocity of infarct-related artery. Major adverse cardiovascular events (MACEs) included cardiac death and re-hospitalization for congestive heart failure.RESULTS:
During the mean follow-up of 85+/-43 months, MACEs occurred in 17.2% of patients. Using a receiver-operating characteristics analysis, hMVRI >2.82 mm Hg.cm-1.sec (sensitivity 87%; specificity 69%; and area under curve 0.818) was the best cut-off values for predicting future cardiac events. The Cox proportional hazard analysis showed that hMVRI was an independent predictor for long-term MACEs (hazard ratio 1.741, 95% confidence interval 1.348-2.264, p2.82 mm Hg.cm-1.sec (p<0.001).CONCLUSION:
hMVRI was a strong predictor of long-term MACEs in patients with STEMI treated with primary PCI.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Artérias
/
Incidência
/
Seguimentos
/
Sensibilidade e Especificidade
/
Área Sob a Curva
/
Morte
/
Intervenção Coronária Percutânea
/
Pressão Arterial
/
Insuficiência Cardíaca
/
Microcirculação
Tipo de estudo:
Estudo diagnóstico
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Circulation Journal
Ano de publicação:
2015
Tipo de documento:
Artigo
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