Differential Regulation of Atrial Natriuretic Peptide in Clipped and Contralateral Kidneys in Two-Kidney, One Clip Hypertension / 대한신장학회잡지
Korean Journal of Nephrology
;
: 728-733, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-196180
ABSTRACT
BACKGROUND:
The present study was aimed to determine the pathophysiological implications of local atrial natriuretic peptide (ANP) system in the kidney in two- kidney, one clip (2K1C) hypertension.METHODS:
Rats were made 2K1C hypertensive, and their mRNA expressions of ANP and natriuretic peptide receptors (NPR) were determined in the clipped and contralateral kidneys by reverse transcription-polymerase chain reaction.RESULTS:
The expression of ANP was decreased in the clipped kidney and increased in the contralateral kidney. Similarly, the expression of both NPR-A and NPR-C was decreased in the clipped kidney and increased in the contralateral kidney.CONCLUSION:
These findings indicate a differentially-altered ANP system in the clipped and the contralateral kidneys in 2K1C hypertension.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
RNA Mensageiro
/
Fator Natriurético Atrial
/
Receptores de Peptídeos
/
Hipertensão
/
Rim
Limite:
Animais
Idioma:
Coreano
Revista:
Korean Journal of Nephrology
Ano de publicação:
2002
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS