Clinical and Histopathologic Studies of Lupus Erythematosus Panniculitis in Korea / 대한피부과학회지
Korean Journal of Dermatology
;
: 912-918, 2005.
Artigo
em Coreano
| WPRIM
| ID: wpr-196343
ABSTRACT
BACKGROUND:
Lupus erythematosus panniculitis (LEP), (or lupus erythematosus profundus), is an unusual variant of lupus erythematosus which primarily affects subcutaneous fat. LEP may occur with or without other manifestations of cutaneous or systemic lupus erythematosus. Only a few studies on the clinical and histopathologic manifestation of LEP have been conducted in Korea.OBJECTIVE:
The purpose of this study was to investigate clinical, laboratory, and histopathologic features of LEP in Korean patients.METHOD:
A total of 30 patients confirmed as having LEP at the Chungbuk National University Hospital between 1 July 1994 and 31 June 2004 were included in this study. The medical records and histopathologic findings were reviewed. RESULTS ANDCONCLUSION:
1. LEP occurred predominantly in females, with the female to male ratio being 4 1. The mean age at diagnosis was 38.5 years. 2. The most common clinical features were nodules or plaques, and 60% of the patients had pain or tenderness. Skin lesions affected the proximal arm area, face, trunk, scalp, and buttocks. In 26% of cases, LEP was associated with discoid lupus erythematosus (DLE), and 13% had evidence of mild systemic lupus erythematosus (SLE). The antinuclear antibody (ANA) was positive in 30% of cases. 3. The main histopathologic characteristics of LEP were predominant lymphocytic lobular panniculitis, hyaline necrosis, mucin deposit, and lymphoid aggregates. 4. Treatments included antimalarial drugs, systemic corticosteroids, intralesional corticosteroids, or topical potent corticosteroids under occlusion. They produced some improvement in most cases, however LEP exhibited a chronic nature with a high relapse rate.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Braço
/
Recidiva
/
Couro Cabeludo
/
Pele
/
Nádegas
/
Lúpus Eritematoso Discoide
/
Paniculite
/
Paniculite de Lúpus Eritematoso
/
Prontuários Médicos
/
Anticorpos Antinucleares
Tipo de estudo:
Estudo diagnóstico
Limite:
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Ano de publicação:
2005
Tipo de documento:
Artigo
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