Ubiquitination of Aquaporin: in the kidney
Electrolytes & Blood Pressure
;
: 1-4, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-196692
ABSTRACT
Ubiquitination is known to be important for endocytosis and lysosomal degradation of aquaporin-2 (AQP2). Ubiquitin (Ub) is covalently attached to the lysine residue of the substrate proteins and activation and attachment of Ub to a target protein is mediated by the action of three enzymes (i.e., E1, E2, and E3). In particular, E3 Ub-protein ligases are known to have substrate specificity. This minireview will discuss the ubiquitination of AQP2 and identification of potential E3 Ub-protein ligases for 1-deamino-8-D-arginine vasopressin (dDAVP)-dependent AQP2 regulation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Especificidade por Substrato
/
Vasopressinas
/
Proteínas
/
Ubiquitina
/
Desamino Arginina Vasopressina
/
Endocitose
/
Aquaporina 2
/
Ubiquitinação
/
Rim
/
Túbulos Renais Coletores
Idioma:
Inglês
Revista:
Electrolytes & Blood Pressure
Ano de publicação:
2009
Tipo de documento:
Artigo
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