Practice patterns of adjuvant therapy for intermediate/high recurrence risk cervical cancer patients in Japan / 부인종양
Journal of Gynecologic Oncology
;
: e29-2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-196713
ABSTRACT
OBJECTIVE:
Although radiation therapy (RT) and concurrent chemoradiotherapy (CCRT) are the global standards for adjuvant therapy treatment in cervical cancer, many Japanese institutions choose chemotherapy (CT) because of the low frequency of irreversible adverse events. In this study, we aimed to clarify the trends of adjuvant therapy for intermediate/high-risk cervical cancer after radical surgery in Japan.METHODS:
A questionnaire survey was conducted by the Japanese Gynecologic Oncology Group to 186 authorized institutions active in the treatment of gynecologic cancer.RESULTS:
Responses were obtained from 129 facilities. Adjuvant RT/CCRT and intensity-modulated RT were performed in 98 (76%) and 23 (18%) institutions, respectively. On the other hand, CT was chosen as an alternative in 93 institutions (72%). The most common regimen of CT, which was used in 66 institutions (51%), was a combination of cisplatin/carboplatin with paclitaxel. CT was considered an appropriate alternative option to RT/CCRT in patients with risk factors such as bulky tumors, lymph node metastasis, lymphovascular invasion, parametrial invasion, and stromal invasion. The risk of severe adverse events was considered to be lower for CT than for RT/CCRT in 109 institutions (84%).CONCLUSION:
This survey revealed a variety of policies regarding adjuvant therapy among institutions. A clinical study to assess the efficacy or non-inferiority of adjuvant CT is warranted.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Padrões de Prática Médica
/
Neoplasias do Colo do Útero
/
Inquéritos e Questionários
/
Fatores de Risco
/
Terapia Combinada
/
Medição de Risco
/
Quimiorradioterapia Adjuvante
/
Japão
/
Recidiva Local de Neoplasia
Tipo de estudo:
Estudo de etiologia
/
Guia de Prática Clínica
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Journal of Gynecologic Oncology
Ano de publicação:
2016
Tipo de documento:
Artigo
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