The Use of Ascorbic Acid after Excimer Laser Photo refractive Keratectomy in Rabbits
Journal of the Korean Ophthalmological Society
;
: 1620-1625, 1996.
Artigo
em Coreano
| WPRIM
| ID: wpr-196896
ABSTRACT
Polymorphonuclear leukocytes(PMNs) infiltrate to the wound site within a few hours after excimer laser photorefractive keratectomy(PRK). Oxygen free radicals produced by the PMNs may be injurious to the surrounding corneal tissues and also acts as an inflammatory mediator that deepen tissue damage. In this study we examined that the application of ascorbic acid would decrease corneal haze following excimer laser PRK. Excimer laser PRK was done in 9 rabbits (18 eyes). Ascorbic acid was injected subconjunctivally in one eye and BSS was injected in the opposite eye. The corneal epithelium re-surfaced by 2.6 +/- 0.5 days in the ascorbic acid treated group and by 2.7 +/- 0.7 days in the ESS injected group. Corneal hazes examined in postop 2wk, 4 wk, 6 wk, and 8 wk were 1.6 +/- 0.5, 1.4 +/- 0.5, 0.7 +/- 0.3, 0.5 +/- 0.2 in the ascorbic acid treated group and 2.1 +/- 0.6, 1.7 +/- 0.5, 1.1 +/- 0.3, 0.9 +/- 0.2 in the BSS injected group, respectively. These data suggest that ascorbic acid would decrease corneal haze after excimer laser PRK without significant complications.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxigênio
/
Ácido Ascórbico
/
Ferimentos e Lesões
/
Epitélio Corneano
/
Lasers de Excimer
/
Radicais Livres
Limite:
Animais
Idioma:
Coreano
Revista:
Journal of the Korean Ophthalmological Society
Ano de publicação:
1996
Tipo de documento:
Artigo
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