MMP-1 promoter polymorphism in Korean with generalized aggressive periodontitis / 대한치주과학회지
The Journal of the Korean Academy of Periodontology
;
: 269-278, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-196933
ABSTRACT
PURPOSE:
The aim of this study was to investigate matrix metalloproteinase 1 (MMP-1) gene polymorphism (1G/2G at -1607 and A/G at -519) in Korean subject and to assess the association between polymorphism and periodontal status.METHODS:
Forty nine generalized aggressive periodontitis (GAP) patients and 57 periodontally healthy children were recruited and genomic DNA was extracted from buccal swab. The polymorphisms of MMP-1 promoter genes were determined by polymerase chain reaction and restriction fragment length product (PCR-RFLP) method. The distribution of genotype and allele frequency was compared between 2 groups by chi-square test.RESULTS:
There was a significant difference in the distribution of genotypes and frequency of alleles between the GAP and reference groups at the position - 519 of MMP-1 gene promoter (P< 0.05). Allele G carrier rate was significantly lower in GAP group than that of the reference group (P< 0.001). At the position -1607 of MMP-1 gene promoter, genotype distribution and allele frequency showed no statistically significant difference between the groups. However, in the female group, a significant difference was observed between the groups for the genotype distribution, allele frequency and allele 1G carrier rate (P< 0.05).CONCLUSIONS:
The DNA polymorphism at the MMP-1 gene promoter might be associated with GAP in Korean.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Periodontite Agressiva
/
Polimorfismo Genético
/
DNA
/
Reação em Cadeia da Polimerase
/
Metaloproteinase 1 da Matriz
/
Alelos
/
Frequência do Gene
/
Genótipo
Limite:
Criança
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
The Journal of the Korean Academy of Periodontology
Ano de publicação:
2009
Tipo de documento:
Artigo
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