The Effects of Hydroxyapatite-Chitosan Membrane on Bone Regeneration in Rat Calvarial Defects / 대한치주과학회지
The Journal of the Korean Academy of Periodontology
;
: 213-222, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-196939
ABSTRACT
PURPOSE:
Recently, interest in chitosan has increased due to its excellent biological properties such as biocompatibility, antibacterial effect, and rapid healing capacity. On the other hand, hydroxyapatite is used as a bone substitute in the fields of orthopedics and dentistry. The hydroxyapatite-chitosan (HA-CS) complex containing hydroxyapatite nanoparticles was developed for synergy of both biomaterials. The objective of this study was to evaluate the effect of hydroxyapatite (HA)-chitosan (CS) membrane on bone regeneration in the rat calvarial defect.METHODS:
Eight-millimeter critical-sized calvarial defects were created in 70 male Sprague-Dawley rats. The animals were divided into 7 groups of 10 animals and received either 1) chitosan (CS) 100% membrane, 2) hydroxyapatite (HA) 30%/ CS 70% membrane, 3) HA 30% / CS 70%, pressed membrane, 4) HA 40%/ CS 60% membrane, 5) HA 50%/ CS 50% membrane, 6) HA 50%/ CS 50%, pressed membrane, or 7) a sham - surgery control. The amount of newly formed bone from the surface of the rat calvarial defects was measured using histomorphometry, following 2- or 8- week healing intervals.RESULTS:
Surgical implantation of the HA - CS membrane resulted in enhanced local bone formation at both 2 and 8 weeks compared to the control group. The HA - CS membrane would be significantly more effective than the chitosan membrane in early bone formation.CONCLUSIONS:
Concerning the advantages of biomaterials, the HA-CS membrane would be an effective biomaterial for regeneration of periodontal bone. Further studies will be required to improve the mechanical properties to develop a more rigid scaffold for the HA-CS membrane.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ortopedia
/
Osteogênese
/
Regeneração
/
Materiais Biocompatíveis
/
Regeneração Óssea
/
Salicilamidas
/
Ratos Sprague-Dawley
/
Durapatita
/
Substitutos Ósseos
/
Odontologia
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
The Journal of the Korean Academy of Periodontology
Ano de publicação:
2009
Tipo de documento:
Artigo
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