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Effect of Beraprost Sodium in Patients with Chronic Obstructive Pulmonary Disease / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases ; : 320-328, 2004.
Artigo em Coreano | WPRIM | ID: wpr-197208
ABSTRACT

BACKGROUND:

Pulmonary vascular changes which occur early in the course of chronic obstructive pulmonary disease (COPD) are prevalent manifestation and later cause pulmonary hypertension, which is a bad prognostic factor in COPD. Beraprost sodium (BPS), an orally active prostacyclin analogue, has been shown to improve survival in patients with primary pulmonary hypertension. This study investigated the effect of BPS in the patients with COPD.

METHODS:

This is a double-blind randomized placebo-controlled, two center clinical trial. Twenty one consecutive patients with COPD were enrolled from June 2003 to June 2004 (patients treated with BPS for 3 months, BPS group, n=11; those with placebo, placebo group, n=10). The baseline demographic, pulmonary function and hemodynamic data were not significantly different between two groups.

RESULTS:

On echocardiographic examination, trans tricuspid valve pressure gradient has decreased significantly after 3 months with beraprost in the BPS group [17.7(+/-11.4) to 8.2(+/-8.9) mm Hg, p-value<0.05], while there was no significant change in the control group. Six-minute walking distance has decreased in the control group and increased in the BPS group, but there was no statistical significance.

CONCLUSION:

In patients with COPD oral administration of BPS reduced the pulmonary arterial pressure. The clinical significance of this finding, that is improving symptoms and natural course of the disease, needs further study.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sódio / Valva Tricúspide / Ecocardiografia / Administração Oral / Caminhada / Epoprostenol / Doença Pulmonar Obstrutiva Crônica / Pressão Arterial / Hemodinâmica / Hipertensão Pulmonar Tipo de estudo: Ensaio Clínico Controlado / Estudo prognóstico Limite: Humanos Idioma: Coreano Revista: Tuberculosis and Respiratory Diseases Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sódio / Valva Tricúspide / Ecocardiografia / Administração Oral / Caminhada / Epoprostenol / Doença Pulmonar Obstrutiva Crônica / Pressão Arterial / Hemodinâmica / Hipertensão Pulmonar Tipo de estudo: Ensaio Clínico Controlado / Estudo prognóstico Limite: Humanos Idioma: Coreano Revista: Tuberculosis and Respiratory Diseases Ano de publicação: 2004 Tipo de documento: Artigo