The Relationship between the p27 Expression of Papillary Thyroid Cancer Cells Obtained by FNA and Cervical Lymph Node Metastasis / 대한내분비외과학회지
Korean Journal of Endocrine Surgery
;
: 155-160, 2009.
Artigo
em Coreano
| WPRIM
| ID: wpr-19737
ABSTRACT
PURPOSE:
The p27 gene as a tumor suppressor gene is associated with colorectal cancer, gastric cancer and breast cancer. Some studies have shown a relationship between the underexpression of p27 and lymph node metastasis in papillary thyroid carcinoma. The aim of this study is to evaluate the relationship between a p27 expression of the papillary thyroid cancer cells obtained by fine needle aspiration (FNA) and cervical lymph node metastasis.METHODS:
This study included 60 patients with papillary thyroid cancer and who underwent total thyroidectomy or lobectomy. Central lymph node dissection was routinely done. Out of these patients, 30 patients underwent a FNA procedure during the operation. Immunohistochemical staining for p27 antibody was performed on the papillary thyroid cancer tissues and cells.RESULTS:
Cervical lymph node metastasis is correlated with the tumor size and lymphovascular invasion (P<0.001). The underexpression of p27 for the papillary thyroid cancer tissues and cells was associated with lymph node metastasis (P=0.009).CONCLUSION:
An evaluation of the p27 expression for the papillary thyroid cancer cells obtained by FNA may be useful as a predictor for lymph node metastasis before surgery.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Gástricas
/
Glândula Tireoide
/
Tireoidectomia
/
Neoplasias da Mama
/
Neoplasias da Glândula Tireoide
/
Neoplasias Colorretais
/
Genes Supressores de Tumor
/
Biópsia por Agulha Fina
/
Excisão de Linfonodo
/
Linfonodos
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Endocrine Surgery
Ano de publicação:
2009
Tipo de documento:
Artigo
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