The effect of gender on EC50 of remifentanil to prevent pain during injection of microemulsion propofol / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 504-509, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-197379
ABSTRACT
BACKGROUND:
Propofol injection pain is an unpleasant experience to patients and its prevalence can be influenced by age and gender. We determined the half maximal effective concentration (EC50) of remifentanil for preventing the microemulsion propofol injection pain in the male and female adult groups.METHODS:
After institutional review board approval, a total of 60 patients were assigned into 2 groups depending on their gender group M (male, 20-65 yr) and group F (female, 20-65 yr). Anesthesia was induced with propofol and remifentanil, by a target-controlled infusion. Target effect-site concentration (Ce) of propofol and remifentanil for the first patient started at 4.0 ug/ml and 4.0 ng/ml. Ce of remifentanil for each subsequent patient was determined by the response of the previous patient by the Dixon's up-and-down method (DUDM) with an interval of 0.2 ng/ml. After equilibration of plasma and effect site remifentanil concentration, propofol was administered, and the pain responses were observed.RESULTS:
The remifentanil EC50 was 3.8 +/- 0.2 and 2.7 +/- 0.2 ng/ml in groups M and F, respectively, by DUDM. From Probit regression model, the remifentanil EC50 was 3.7 (3.0-4.3) and 2.7 (1.8-2.9) ng/ml in groups M and F, respectively.CONCLUSIONS:
The remifentanil EC50 for preventing the moderate to severe injection pain of propofol was higher in males than in females.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Piperidinas
/
Plasma
/
Propofol
/
Prevalência
/
Comitês de Ética em Pesquisa
/
Identidade de Gênero
/
Anestesia
Tipo de estudo:
Estudo de prevalência
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2012
Tipo de documento:
Artigo
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