Acute Respiratory Distress Syndrome as the Initial Clinical Manifestation of an Antisynthetase Syndrome / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 188-192, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-197487
ABSTRACT
Antisynthetase syndrome has been recognized as an important cause of autoimmune inflammatory myopathy in a subset of patients with polymyositis and dermatomyositis. It is associated with serum antibody to aminoacyl-transfer RNA synthetases and is characterized by a constellation of manifestations, including fever, myositis, interstitial lung disease, mechanic's hand-like cutaneous involvement, Raynaud phenomenon, and polyarthritis. Lung disease is the presenting feature in 50% of the cases. We report a case of a 60-year-old female with acute respiratory distress syndrome (ARDS), which later proved to be an unexpected and initial manifestation of anti-Jo-1 antibody-positive antisynthetase syndrome. The present case showed resolution of ARDS after treatment with high-dose corticosteroids. Given that steroids are not greatly beneficial in the treatment of ARDS, it is likely that the improvement of the respiratory symptoms in this patient also resulted from the prompt suppression of the inflammatory systemic response by corticosteroids.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Artrite
/
Doença de Raynaud
/
Síndrome do Desconforto Respiratório
/
Esteroides
/
Imunoglobulinas
/
RNA
/
Polimiosite
/
Corticosteroides
/
Doenças Pulmonares Intersticiais
/
Dermatomiosite
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Tuberculosis and Respiratory Diseases
Ano de publicação:
2016
Tipo de documento:
Artigo
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