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Nicotinamide Reduces Amyloid Precursor Protein and Presenilin 1 in Brain Tissues of Amyloid Beta-Tail Vein Injected Mice
Clinical Nutrition Research ; : 130-135, 2017.
Artigo em Inglês | WPRIM | ID: wpr-197945
ABSTRACT
The purpose of this study is to investigate whether nicotinic acid (NA) and nicotinamide (NAM) reduce the Alzheimer disease (AD)-related gene expression in brain tissues of amyloid beta (Aβ)-injected mice. Male CrjCD1 (ICR) mice were divided into 6 treatment groups; 1) control, 2) Aβ control, 3) Aβ + NA 20 mg/kg/day (NA20), 4) Aβ + NA40, 5) Aβ + NAM 200 mg/kg/day (NAM200), and 6) Aβ + NAM400. After 1-week acclimation period, the mice orally received NA or NAM once a day for a total of 7 successive days. On day 7, biotinylated Aβ42 was injected into mouse tail vein. At 5 hours after the injection, blood and tissues were collected. Aβ42 injection was confirmed by Western blot analysis of Aβ42 protein in brain tissue. NAM400 pre-treatment significantly reduced the gene expression of amyloid precursor protein and presenilin 1 in brain tissues. And, NAM200 and NAM400 pre-treatments significantly increased sirtuin 1 expression in brain tissues, which is accompanied by the decreased brain expression of nuclear factor kappa B by 2 doses of NAM. Increased expression of AD-related genes was attenuated by the NAM treatment, which suggests that NAM supplementation may be a potential preventive strategy against AD-related deleterious changes.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Cauda / Veias / Encéfalo / Envelhecimento / Expressão Gênica / Western Blotting / NF-kappa B / Niacinamida / Presenilinas / Presenilina-1 Limite: Animais / Humanos / Masculino Idioma: Inglês Revista: Clinical Nutrition Research Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Cauda / Veias / Encéfalo / Envelhecimento / Expressão Gênica / Western Blotting / NF-kappa B / Niacinamida / Presenilinas / Presenilina-1 Limite: Animais / Humanos / Masculino Idioma: Inglês Revista: Clinical Nutrition Research Ano de publicação: 2017 Tipo de documento: Artigo