Treatment of Intravenous Immune-Globulin Resistant Kawasaki Disease with Corticosteroids
Journal of the Korean Pediatric Society
; : 1453-1457, 1997.
Article
em Ko
| WPRIM
| ID: wpr-198908
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: To evaluate the efficacy of steroid therapy on prevention of development and progression of coronary artery aneurysm in intravenous immune globulin (IVIG)-resistant Kawasaki disease, we treated three children with high dose of intravenous methylprednisolone followed by low dose oral prednisolone. METHODS: We selected three children with Kawasaki disease who did not repond or who initially responded but soon developed recrudescent fever after retreatment of IVIG (total 4gm/kg). These three patients were treated with high dose methylprednisolone (10mg/kg) intravenously and followed by low dose prednisolone (1mg/kg) orally for 7 days. Echocardiographic evalutions were performed within 8 days of admission (before steroid therapy), at discharge and 1 month after discharge. RESULTS: All three patients showed rapid normalization of clinical symptoms and did not developed significant coronry artery abnormalities. No adverse reaction was observed. CONCLUSIONS: Steroid therapy (mini pulse methylprednisolone and prednisolone therapy) is valuable for patients with Kawasaki disease resistant to intravenous immune globulin therapy.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Artérias
/
Metilprednisolona
/
Prednisolona
/
Ecocardiografia
/
Imunoglobulinas Intravenosas
/
Corticosteroides
/
Retratamento
/
Vasos Coronários
/
Febre
/
Aneurisma
Limite:
Child
/
Humans
Idioma:
Ko
Revista:
Journal of the Korean Pediatric Society
Ano de publicação:
1997
Tipo de documento:
Article