The Stem Bark of Kalopanax pictus Exhibits Anti-inflammatory Effect through Heme Oxygenase-1 Induction and NF-kappaB Suppression
Immune Network
; : 212-218, 2010.
Article
em En
| WPRIM
| ID: wpr-198930
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: The stem bark of Kalopanax pictus (KP) has been used in traditional medicine to treat rheumatoidal arthritis, neurotic pain and diabetes mellitus in China and Korea. In this study, the mechanism responsible for anti-inflammatory effects of KP was investigated. METHODS: We examined the effects of KP on NO production, nitric oxide synthase (iNOS) and HO-1 expression, NF-kappaB, Nrf2 and MAPK activation in mouse peritoneal macrophages. RESULTS: The aqueous extract of KP inhibited LPS-induced NO secretion as well as inducible iNOS expression, without affecting cell viability. KP suppressed LPS-induced NF-kappaB activation, phosphorylation and degradation of IkappaB-alpha, phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK). Furthermore, KP induced HO-1 expression and Nrf2 nuclear translocation. CONCLUSION: These results suggest that KP has the inhibitory effects on LPS-induced NO production in macrophages through NF-kappaB suppression and HO-1 induction.
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Assunto principal:
Fosforilação
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Fosfotransferases
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Artrite
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Sobrevivência Celular
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China
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NF-kappa B
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Óxido Nítrico Sintase
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Proteínas I-kappa B
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Kalopanax
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Proteínas Quinases JNK Ativadas por Mitógeno
Limite:
Animals
País/Região como assunto:
Asia
Idioma:
En
Revista:
Immune Network
Ano de publicação:
2010
Tipo de documento:
Article