The Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in the Treatment of Brain Abscess
Journal of Korean Neurosurgical Society
; : 278-283, 2011.
Article
em En
| WPRIM
| ID: wpr-199086
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
The purpose of this study was to evaluate whether 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) can be used to assess the therapeutic response of brain abscess.METHODS:
A study was conducted on 10 consecutive patients with brain abscess. Magnetic resonance imaging (MRI) with diffuse-weighted imaging (DWI) was performed at 3 and 6 weeks after surgical treatment and intravenous antibiotics therapy and FDG-PET at 6 weeks after treatment. The extent of the abscess, signal changes on MRI, and FDG-PET standardized uptake values were analyzed and correlated with the response to therapy.RESULTS:
Aspiration or craniotomy with excision of the abscess followed by intravenous antibiotics for 6-8 weeks resulted in good recovery with no recurrence. In 10 patients, two had low signal intensity on the DWI; one had no uptake on FDG-PET imaging after 6 weeks antibiotics and discontinued intravenous treatment, but the other patient had diffuse, increased uptake on FDG-PET imaging after 6 weeks antibiotics and underwent an additional 2 weeks of intravenous antibiotics. The remaining eight patients had high signals on the DWI. Four had no uptake on FDG-PET imaging and the treatment period varied from 6 to 8 weeks (mean, 6.75 weeks). Among the other four patients, FDG was accumulated in a diffuse or local area corresponding to a high signal area within the DWI and 2 weeks of intravenous antibiotics was added.CONCLUSION:
MRI plus FDG-PET improved the accuracy of assessing therapeutic responses to antibiotics treatment of brain abscess and aided in optimizing therapy.Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Recidiva
/
Encéfalo
/
Abscesso Encefálico
/
Imageamento por Ressonância Magnética
/
Craniotomia
/
Tomografia por Emissão de Pósitrons
/
Abscesso
/
Elétrons
/
Antibacterianos
Limite:
Humans
Idioma:
En
Revista:
Journal of Korean Neurosurgical Society
Ano de publicação:
2011
Tipo de documento:
Article