Fucodiphlorethol G Purified from Ecklonia cava Suppresses Ultraviolet B Radiation-Induced Oxidative Stress and Cellular Damage
Biomolecules & Therapeutics
; : 301-307, 2014.
Article
em En
| WPRIM
| ID: wpr-199232
Biblioteca responsável:
WPRO
ABSTRACT
Fucodiphlorethol G (6'-[2,4-dihydroxy-6-(2,4,6-trihydroxyphenoxy)phenoxy]biphenyl-2,2',4,4',6-pentol) is a compound purified from Ecklonia cava, a brown alga that is widely distributed offshore of Jeju Island. This study investigated the protective effects of fucodiphlorethol G against oxidative damage-mediated apoptosis induced by ultraviolet B (UVB) irradiation. Fucodiphlorethol G attenuated the generation of 2, 2-diphenyl-1-picrylhydrazyl radicals and intracellular reactive oxygen species in response to UVB irradiation. Fucodiphlorethol G suppressed the inhibition of human keratinocyte growth by UVB irradiation. Additionally, the wavelength of light absorbed by fucodiphlorethol G was close to the UVB spectrum. Fucodiphlorethol G reduced UVB radiation-induced 8-isoprostane generation and DNA fragmentation in human keratinocytes. Moreover, fucodiphlorethol G reduced UVB radiation-induced loss of mitochondrial membrane potential, generation of apoptotic cells, and active caspase-9 expression. Taken together, fucodiphlorethol G protected human keratinocytes against UVB radiation-induced cell damage and apoptosis by absorbing UVB radiation and scavenging reactive oxygen species.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Queratinócitos
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Espécies Reativas de Oxigênio
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Apoptose
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Estresse Oxidativo
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Caspase 9
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Fragmentação do DNA
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Potencial da Membrana Mitocondrial
Limite:
Humans
Idioma:
En
Revista:
Biomolecules & Therapeutics
Ano de publicação:
2014
Tipo de documento:
Article