Comparative Analysis Between Thoracic Spinal Cord and Sacral Neuromodulation in a Rat Spinal Cord Injury Model: A Preliminary Report of a Rat Spinal Cord Stimulation Model
Korean Journal of Spine
;
: 14-18, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-199862
ABSTRACT
OBJECTIVE:
The purpose of this study is to compare a neuroprotective effect of thoracic cord neuromodulation to that of sacral nerve neuromodulation in rat thoracic spinal cord injury (SCI) model.METHODS:
Twenty female Sprague Dawley rats were randomly divided into 4 groups the normal control group (n=5), SCI with sham stimulation group (SCI, n=5), SCI with electrical stimulation at thoracic spinal cord (SCI + TES, n=5), and SCI with electrical stimulation at sacral nerve (SCI + SES, n=5). Spinal cord was injured by an impactor which dropped from 25mm height. Electrical stimulation was performed by the following protocol pulse duration, 0.1ms; frequency, 20 Hz; stimulation time, 30 minutes; and stimulation duration at thoracic epidural space and S2 or 3 neural foramina for 4 weeks. Locomotor function, urodynamic study, muscle weights, and fiber cross sectional area (CSA) were investigated.RESULTS:
All rats of the SCI + TES group expired within 3 days after the injury. The locomotor function of all survived rats improved over time but there was no significant difference between the SCI and the SCI + SES group. All rats experienced urinary retention after the injury and recovered self-voiding after 3-9 days. Voiding contraction interval was 25.5+/-7.5 minutes in the SCI group, 16.5+/-5.3 minutes in the SCI+SES group, and 12.5+/-4.2 minutes in the control group. The recovery of voiding contraction interval was significant in the SCI + SES group comparing to the SCI group (p<0.05). Muscle weight and CSA were slightly greater in the SCI + SES than in the SCI group, but the difference was not significant.CONCLUSION:
We failed to establish a rat spinal cord stimulation model. However, sacral neuromodulation have a therapeutic potential to improve neurogenic bladder and muscle atrophy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Medula Espinal
/
Traumatismos da Medula Espinal
/
Trometamina
/
Urodinâmica
/
Pesos e Medidas
/
Bexiga Urinaria Neurogênica
/
Atrofia Muscular
/
Salicilamidas
/
Retenção Urinária
/
Ratos Sprague-Dawley
Tipo de estudo:
Guia de Prática Clínica
Limite:
Animais
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Spine
Ano de publicação:
2013
Tipo de documento:
Artigo
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