Nalbuphine vs. chlorpheniramine in reducing intrathecal opioid-induced pruritus in parturients undergoing lower-segment caesarean section
Brunei International Medical Journal
;
: 128-134, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-20
ABSTRACT
Background:
Pruritus is a common complication of intrathecal opioids and numerous medications have been used to prevent or treat this complication. However, the efficacy of these medications vary. The choice of medications also depends on the availability and the cost. We performed a randomised double-blind study to evaluate whether nalbuphine is as effective as chlorpheniramine, a medication that is commonly used for treating pruritus for the treatment of intrathecal opioid-induced pruritus in parturients undergoing lower-segment caesarean section. Materials andMethods:
Two hundred and thirty four parturients with American Society of Anaesthesiologists (ASA) physical status I or II who had intrathecal opioid-induced pruritus were assigned to receive either intravenous nalbuphine (4 mg eight-hourly) or intravenous chlorpheniramine (5 mg eight-hourly) for a period of 24 hours. Pruritus was assessed using a qualitative scale at pre-treatment, six, nine, 12 and 24 hours post-treatment.Results:
The occurrence of intrathecal opioid-induced pruritus was significantly reduced in parturients treated with intravenous nalbuphine as compared to intravenous chlorpheniramine at all intervals studied.Conclusion:
In conclusion, nalbuphine is more effective than chlorpheniramine in reducing intrathecal opioid-induced pruritus for parturients undergoing lower-segment caesarean section.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Injeções Espinhais
/
Antagonistas dos Receptores Histamínicos H1
/
Analgésicos Opioides
/
Anestesia
Tipo de estudo:
Ensaio Clínico Controlado
/
Pesquisa qualitativa
Limite:
Gravidez
Idioma:
Inglês
Revista:
Brunei International Medical Journal
Ano de publicação:
2012
Tipo de documento:
Artigo
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