IMP3, a Promising Prognostic Marker in Clear Cell Renal Cell Carcinoma
Korean Journal of Pathology
;
: 108-116, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-20021
ABSTRACT
BACKGROUND:
Insulin-like growth factor II mRNA-binding protein 3 (IMP3) has been reported as a prognostic biomarker in various cancers. To validate IMP3 as a prognostic biomarker in renal cell carcinoma (RCC), we investigated the expression of IMP3, p53, and Ki-67, and their associations with clinicopathologic outcomes.METHODS:
We studied 148 clear cell RCCs (CCRCCs) from patients who underwent radical nephrectomy. The expression levels of IMP3, p53, and Ki-67 were assessed by immunohistochemical staining and the clinical and pathologic parameters were retrospectively reviewed.RESULTS:
Twenty-nine percent of CCRCCs expressed IMP3. Forty-one percent of IMP3-immunopositive tumors developed metastases, while only 11.4% of IMP3-negative tumors developed metastases (p<.001). A Kaplan-Meier curve showed that patients with IMP3-immunopositive tumors had lower metastasis-free survival and cancer-specific survival than did those with IMP3-immunonegative tumors (p<.001 and p<.001, respectively). Expression of high Ki-67 proliferation index was also associated with a higher metastatic rate. In the multivariate Cox regression analysis, pT stage and IMP3-positivity were independently associated with disease-specific survival.CONCLUSIONS:
IMP3 is an independent prognostic biomarker for patients with CCRCC to predict metastasis and poor outcome.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fator de Crescimento Insulin-Like II
/
Carcinoma de Células Renais
/
Estudos Retrospectivos
/
Proteína Supressora de Tumor p53
/
Metástase Neoplásica
/
Nefrectomia
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Pathology
Ano de publicação:
2014
Tipo de documento:
Artigo
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