Increased Frequency of Apolipoprotein E4 Genotype in Childhood Minimal Change Nephrotic Syndrome (MCNS)
Journal of the Korean Society of Pediatric Nephrology
;
: 87-99, 2001.
Artigo
em Inglês
| WPRIM
| ID: wpr-200588
ABSTRACT
PURPOSE:
We studied to find out apo-E genotype polymorphism in minimal change nephrotic syndrome(MCNS) and IgA nephropathy(IgAN) and to determine the relationship between apo-E genotype and clinical course of MCNS. MATERIALS ANDMETHOD:
43 MCNS patients and 15 IgAN patients were examined for apo-E polymorphism. 50 healthy blood donors were examined for apo-E genotype as control. Genomic DNA was prepared from peripheral blood leukocytes according to standard procedures.RESULTS:
As compared with control group, e4 allele frequency was significantly increased in MCNS (P<0.01). However, in IgAN e2 allele frequency, however, was 2.6 times higher than normal control (P<0.01). The frequency of e4 allele of frequent relapser group was 4.6 times higher than normal control and was 2 times higher than infrequent relapser group.CONCLUSION:
We think that apo-E typing might be one of the parameters, which should be considered to predict the course of MCNS in children. MCNS with risky HLA profile and E4/4 genotype could indicate the need for a longer steroid dministration. And apo-E genotype needs to be considered for the evaluation of therapeutic responses to other drugs.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Apolipoproteínas
/
Apolipoproteínas E
/
Doadores de Sangue
/
DNA
/
Imunoglobulina A
/
Alelos
/
Apolipoproteína E4
/
Frequência do Gene
/
Genótipo
/
Leucócitos
Tipo de estudo:
Estudo prognóstico
Limite:
Criança
/
Humanos
Idioma:
Inglês
Revista:
Journal of the Korean Society of Pediatric Nephrology
Ano de publicação:
2001
Tipo de documento:
Artigo
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