Reduction of Influenza A (H1N1) Virus Through a Leukoreduction Filter / 대한수혈학회지
Korean Journal of Blood Transfusion
;
: 65-73, 2010.
Artigo
em Coreano
| WPRIM
| ID: wpr-200868
ABSTRACT
BACKGROUND:
Leukoreduction can reduce the risk of HLA alloimmunization, recurrent febrile nonhemolytic transfusion reactions, and several transfusion-transmitted infectious diseases, including cytomegalovirus infection. Transmission of the new influenza A (H1N1) virus through transfusion may be a concern. We evaluated the effect of filtration with a leukoreduction filter on H1N1 genomes.METHODS:
To evaluate the effect of filtration by a leukoreduction filter on H1N1 genomes, we analyzed pre- and post-filtered samples from nasopharyngeal swabs and 10 positive plasma samples using real time RT-PCR.RESULTS:
The 10 samples (nasopharyngeal swabs and plasma) contained H1N1 RNA, and filtration with a leukoreduction filter reduced these levels (threshold cycle values from 31.42+/-2.06 to 38.84+/-1.47 in nasopharyngeal swabs, from 35.63+/-2.19 to 39.38+/-2.65 in plasma samples).CONCLUSION:
Filtration with a leukoreduction filter can reduce H1N1 genome levels, but may not be completely sufficient for total eradication of this pathogen.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Vírus
/
Incompatibilidade de Grupos Sanguíneos
/
RNA
/
Doenças Transmissíveis
/
Genoma
/
Infecções por Citomegalovirus
/
Influenza Humana
/
Filtração
Idioma:
Coreano
Revista:
Korean Journal of Blood Transfusion
Ano de publicação:
2010
Tipo de documento:
Artigo
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