Changes in bone mineral density and trabecular bone score in Graves' disease patients after anti-thyroid therapy
Osteoporosis and Sarcopenia
;
: 175-179, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-201243
ABSTRACT
OBJECTIVE:
The purpose of this study was to evaluate changes in bone quantity based on bone mineral density (BMD) and bone quality based on trabecular bone score (TBS) in Graves' disease patients after anti-thyroid therapy. RESEARCH DESIGN ANDMETHOD:
This retrospective study included premenopausal female and male patients with Graves' disease who received BMD measurement more than two times during treatment. BMD and thyroid function tests with free thyroxine (FT4), total triiodothyronine (T3), thyroid stimulating hormone (TSH), and TSH receptor antibody (TRAb) levels were collected two times during follow-up. TBS was calculated using TBS insight® software (version 2.1) from dual-energy X-ray absorptiometry images.RESULTS:
Thirty Graves' disease patients (17 males, 56%; 13 premenopausal females, 44%) with a mean age of 35.3 ± 9.9 years were included. The mean follow-up period was 20.7 ± 8.5 months. The median levels of FT4, TSH and TRAb improved at follow-up [2.55 ng/dL (Interquartile range (IQR) 2.07-3.78) to 1.28 ng/dL (IQR 1.23-1.39), 0.015 mIU/L (IQR 0.01-0.04) to 0.89 mIU/L (IQR 0.35-1.55), 17.0 IU/L (IQR 5.0-40.3) to 5.0 IU/L (5.0-6.0), respectively; p < 0.001]. Median BMD (lumbar spine) values also improved from 1.118 g/cm² (IQR 1.000-1.119) to 1.167 g/cm² (IQR 1.050-1.219) ( p = 0.001) at follow-up. TBS increased from 1.377 (IQR 1.299-1.422) to 1.390 (IQR 1.327-1.430) after treatment ( p = 0.038).CONCLUSIONS:
Both bone quality and density improved after anti-thyroid treatment in premenopausal female and male Graves' disease patients.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Projetos de Pesquisa
/
Testes de Função Tireóidea
/
Tiroxina
/
Tri-Iodotironina
/
Receptores da Tireotropina
/
Tireotropina
/
Absorciometria de Fóton
/
Densidade Óssea
/
Doença de Graves
/
Estudos Retrospectivos
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Osteoporosis and Sarcopenia
Ano de publicação:
2016
Tipo de documento:
Artigo
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