Effects of retinoic acid on ischemic brain injury-induced eurogenesis
Experimental & Molecular Medicine
;
: 304-315, 2007.
Artigo
em Inglês
| WPRIM
| ID: wpr-201424
ABSTRACT
Neurogenesis can be induced by pathological conditions such as cerebral ischemia. However the molecular mechanisms or modulating reagents of the reactive neurogenesis after the cerebral ischemia are poorly characterized. Retinoic acid (RA) has been shown to increase neurogenesis by enhancing the proliferation and neuronal differentiation of forebrain neuroblasts. Here, we examined whether RA can modulate the reactive neurogenesis after the cerebral ischemia. In contrast to our expectation, RA treatment decreased the reactive neurogenesis in subventricular zone (SVZ), subgranular zone (SGZ) and penumbral region. Furthermore, RA treatment also decreased the angiogenesis and gliosis in penumbral region.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tretinoína
/
Encéfalo
/
Diferenciação Celular
/
Ataque Isquêmico Transitório
/
Neuroglia
/
Ratos Sprague-Dawley
/
Proliferação de Células
/
Neovascularização Patológica
/
Neurônios
Limite:
Animais
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2007
Tipo de documento:
Artigo
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