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Detection of Clarithromycin-resistant Strains from Clinical Isolates of Mycobacterium abscessus / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases ; : 422-426, 2008.
Artigo em Coreano | WPRIM | ID: wpr-201625
ABSTRACT

BACKGROUND:

Mycobacterium abscessus is the most pathogenic and drug-resistant rapid-growing mycobacterium. Clarithromycin or azithromycin are the only regular oral antimycobacterial agents that have an effect on M. abscessus. We tried to detect the clarithromycin-resistant strains from the clinical isolates of M. abscessus.

METHODS:

We tried to isolate the clarithromycin-resistant strains from 220 clinical isolates of M. abscessus by performing using reverse hybridization assay (RHA) and the broth microdilution test (BMT).

RESULTS:

Seven resistant strains (3.2%) from all the tested clinical isolates were detected by BMT. Three of these resistant strains were also detected by RHA and it was confirmed that they had point mutants.

CONCLUSION:

These results showed that clarithromycin resistance in M. abscessus clinical isolates is related to a point mutation and other unknown mechanisms.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Quimera / Mutação Puntual / Claritromicina / Azitromicina / Antibacterianos / Mycobacterium Tipo de estudo: Estudo diagnóstico Idioma: Coreano Revista: Tuberculosis and Respiratory Diseases Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Quimera / Mutação Puntual / Claritromicina / Azitromicina / Antibacterianos / Mycobacterium Tipo de estudo: Estudo diagnóstico Idioma: Coreano Revista: Tuberculosis and Respiratory Diseases Ano de publicação: 2008 Tipo de documento: Artigo