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Clinical Response to Etoposide Plus Carboplatin and Topotecan Chemotherapy in Small Cell Lung Cancer / 결핵
Tuberculosis and Respiratory Diseases ; : 415-428, 2003.
Artigo em Coreano | WPRIM | ID: wpr-201975
ABSTRACT

BACKGROUND:

This study assessed the efficacy and toxicity of etoposide and carboplatin(EC) combination regimen as a first line therapy for small cell lung cancer(SCLC), and determined the efficacy and toxicity of topotecan for relapsed SCLC.

METHODS:

One hundred and ten patients with previously untreated SCLC received etoposide(100mg/m2 i.v., day 1 to 3) and carboplatin(300mg/m2 i.v., day 1) combination chemotherapy every 3 weeks. For patients with relapsed SCLC after EC therapy, topotecan(1.5mg/m2) was administered for 5 consecutive days every 3 weeks. Response rate, survival and toxicity profiles were assessed. Response was recorded as CR(complete remission), PR(partial remission), SD(stable disease) and PD(progressive disease).

RESULTS:

One hundred and one patients were assessed for response to EC. Overall response rate to EC was 57.4%(CR 15.8%, PR 41.6%) with a time to progression of 10.3 months(median). The toxicity was tolerable and there was no treatment-related death. Twenty one relapsed SCLC patients were treated with topotecan. Of those who relapsed within 3 months of EC(refractory relapse, RR), 15.4%(2/13) showed PR, while of those who relapsed after 3 months(sensitive relapse, SR), 25%(2/8) exhibited PR. Grade 4 neutropenia was noted in 9.5% and 14.3% showed thrombocytopenia(G4).

CONCLUSION:

The EC regimen showed a moderate response rate for SCLC with minimal toxicity. The use of topotecan for relapsed SCLC warrants further investigation.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Recidiva / Taxa de Sobrevida / Carboplatina / Topotecan / Tratamento Farmacológico / Quimioterapia Combinada / Etoposídeo / Carcinoma de Pequenas Células do Pulmão / Pulmão / Neutropenia Limite: Humanos Idioma: Coreano Revista: Tuberculosis and Respiratory Diseases Ano de publicação: 2003 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Recidiva / Taxa de Sobrevida / Carboplatina / Topotecan / Tratamento Farmacológico / Quimioterapia Combinada / Etoposídeo / Carcinoma de Pequenas Células do Pulmão / Pulmão / Neutropenia Limite: Humanos Idioma: Coreano Revista: Tuberculosis and Respiratory Diseases Ano de publicação: 2003 Tipo de documento: Artigo