A Case of Acute Pulmonary Embolism Associated with Dysplasminogenemia
Journal of Korean Medical Science
; : 959-961, 2013.
Article
em En
| WPRIM
| ID: wpr-202308
Biblioteca responsável:
WPRO
ABSTRACT
The incidence of pulmonary embolism (PE) rises markedly with age, and only a few cases have been reported in younger adults. Thrombophilia has been reported as one of the predisposing factors for PE in younger adults. Here we report an extraordinary case of PE complicated with dysplasminogenemia, a rare genetic disorder resulting in hypercoagulability, in a young male. An 18-yr-old male visited an emergency room in the United States complaining chest discomfort. He was diagnosed as PE with deep vein thrombosis without apparent risk factors. Anticoagulation therapy with warfarin had been initiated and discontinued after 6 months of treatment. After returning to Korea he was tested for thrombophilia which revealed decreased activity of plasminogen and subsequent analysis of PLG gene showed heterozygous Ala620Thr mutation. He was diagnosed with PE complicated with dysplasminogenemia. Life-long anticoagulation therapy was initiated. He is currently under follow-up without clinical events for 2 yr.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Plasminogênio
/
Embolia Pulmonar
/
Dermatopatias Genéticas
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Varfarina
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Tomografia Computadorizada por Raios X
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Doença Aguda
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Fatores de Risco
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Conjuntivite
/
Trombose Venosa
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Polimorfismo de Nucleotídeo Único
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Humans
/
Male
Idioma:
En
Revista:
Journal of Korean Medical Science
Ano de publicação:
2013
Tipo de documento:
Article