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Endothelial Dysfunction and Increased Carotid Intima-Media Thickness in the Patients with Slow Coronary Flow
Journal of Korean Medical Science ; : 614-618, 2012.
Artigo em Inglês | WPRIM | ID: wpr-202339
ABSTRACT
Flow mediated brachial dilatation (FMD) and carotid intima-media thickness (IMT) have been a surrogate for early atherosclerosis. Slow coronary flow in a normal coronary angiogram is not a rare condition, but its pathogenesis remains unclear. A total of 85 patients with angina were evaluated of their brachial artery FMD, carotid IMT and conventional coronary angiography. Coronary flow was quantified using the corrected thrombosis in myocardial infarction (TIMI) frame count method. Group I was a control with normal coronary angiography (n = 41, 56.1 +/- 8.0 yr) and group II was no significant coronary stenosis with slow flow (n = 44, 56.3 +/- 10.0 yr). Diabetes was rare but dyslipidemia and family history were frequent in group II. Heart rate was higher in group II than in group I. White blood cells, especially monocytes and homocysteine were higher in group II. The FMD was significantly lower in group II than in group I. Elevated heart rate, dyslipidemia and low FMD were independently related with slow coronary flow in regression analysis. Therefore, endothelial dysfunction may be an earlier vascular phenomenon than increased carotid IMT in the patients with slow coronary flow.
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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Artéria Braquial / Endotélio Vascular / Monócitos / Análise de Regressão / Fatores de Risco / Curva ROC / Angiografia Coronária / Circulação Coronária / Dislipidemias / Espessura Intima-Media Carotídea Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Estudo prognóstico / Fatores de risco Limite: Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 2012 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Artéria Braquial / Endotélio Vascular / Monócitos / Análise de Regressão / Fatores de Risco / Curva ROC / Angiografia Coronária / Circulação Coronária / Dislipidemias / Espessura Intima-Media Carotídea Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Estudo prognóstico / Fatores de risco Limite: Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 2012 Tipo de documento: Artigo