Clinical manifestations for diabetes mellitus in HIV-infected Koreans on highly active antiretroviral therapy / 대한내과학회지
Korean Journal of Medicine
;
: 506-514, 2008.
Artigo
em Coreano
| WPRIM
| ID: wpr-202988
ABSTRACT
BACKGROUND/AIMS:
The introduction of highly active antiretroviral therapy (HAART) has significantly modified the course of HIV infection. However, the HAART regimens, and especially those including protease inhibitors (PIs), have been shown to cause diabetes mellitus. We evaluated the incidence and clinical manifestations of HIV-infected Koreans who received HAART and the risk factors for diabetes mellitus in those patients.METHODS:
We conducted a retrospective cohort study and a case-control study to evaluate the clinical manifestations, the incidence and the risk factors for diabetes mellitus in 215 HIV-infected patients who were on HAART at Yonsei University College of Medicine from 1991 to 2006.RESULTS:
215 patients were analyzed and the total duration of follow up was 1079 person-years. The incidences of diabetes mellitus and impaired fasting glucose were 1.39 case/100person-years and 6.02 case/100person-years. Most of the cases were non-obese type II diabetes and these patients showed insulin resistance and impaired beta cell function. On the risk factor analysis, the factors contributing to the development of diabetes were age, a decrease of the viral load and indinavir use.CONCLUSIONS:
In our study, the incidence of diabetes among Korean HIV-positive patients on HAART was 1.39case/100person-years. Age, a decrease of the viral load and indinavir use were the risk factors for development of diabetes mellitus.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Inibidores de Proteases
/
Resistência à Insulina
/
Estudos de Casos e Controles
/
Infecções por HIV
/
Incidência
/
Estudos Retrospectivos
/
Fatores de Risco
/
Estudos de Coortes
/
Seguimentos
/
Síndrome da Imunodeficiência Adquirida
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Ano de publicação:
2008
Tipo de documento:
Artigo
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