Sorafenib-induced Syringoma-like Eccrine Duct Proliferation in a Patient with Hepatocellular Carcinoma / 대한피부과학회지
Korean Journal of Dermatology
; : 246-248, 2017.
Article
em Ko
| WPRIM
| ID: wpr-203541
Biblioteca responsável:
WPRO
ABSTRACT
Syringomas are common benign neoplasms that are derived from the intradermal eccrine duct and frequently manifest in adult females as 1~3-mm flesh-colored papules on the face, especially on the lower eyelid. There are two hypotheses about their pathogenesis: ductal obstruction by keratin plugs and reactive eccrine proliferation following an inflammatory condition. The patient was a 66-year-old man with multiple erythematous papules and nodules on both periorbital areas after 7-day sorafenib (Nexavar®) treatment. A skin biopsy of the Rt. periorbital lesion revealed multiple cysts and tadpole-shaped tubular structures in the dermal layer. Inflammatory cell infiltration was seen throughout the dermis. Based on the clinical features and histological findings, we diagnosed the patient with syringoma-like eccrine duct proliferation. The indications for and use of Sorafenib have increased recently. Although sorafenib-associated cutaneous side effects have increased, no cases of syringoma-like eccrine duct proliferation have been reported to date. Here we report a case of sorafenib-induced syringoma-like eccrine duct proliferation in a patient with hepatocellular carcinoma.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Pele
/
Biópsia
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Siringoma
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Carcinoma Hepatocelular
/
Derme
/
Pálpebras
Limite:
Adult
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Aged
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Female
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Humans
Idioma:
Ko
Revista:
Korean Journal of Dermatology
Ano de publicação:
2017
Tipo de documento:
Article