A Study on the Effect of Various Dosage of Khellin on Epidermal Melanocytes and a Comparison with Trimethylpsoralen in Systemic Photochemotherapy / 대한피부과학회지
Korean Journal of Dermatology
;
: 828-838, 1988.
Artigo
em Coreano
| WPRIM
| ID: wpr-203680
ABSTRACT
Ninety black C 57 BL mice were divided into control and photochemotherapy groups. Control group was subdivided into a UVA 1rradiation only subgroup and a khellin only administration subgroup, while the phototherapy group was subdivided into one TMP and two khellin administration subgroups with dosages of 1.5mg/kg, 5mg/kg and 20mg/kg, respectivly. UVA was administered three thimes a week in a dose of 4J/cm for 4 weeks. Skin biopsies were taken at 0, l, 2, 3 and 4 weeks and the split DOPA stain was employed to observe pigment production. The number, size and circumference of the melanocytes were assessed. In summary, our results inclicate that khellin, which is slightly less effective than TMP at the same effective dose, is quite effective for pigment production and the degree of the production is dose related.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fototerapia
/
Fotoquimioterapia
/
Pele
/
Timidina Monofosfato
/
Trioxsaleno
/
Biópsia
/
Di-Hidroxifenilalanina
/
Quelina
/
Melanócitos
Limite:
Animais
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Ano de publicação:
1988
Tipo de documento:
Artigo
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