Development of Clevudine Resistance after Switching from Lamivudine in a Patient with Chronic Hepatitis B / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 325-328, 2008.
Artigo
em Coreano
| WPRIM
| ID: wpr-204248
ABSTRACT
Clevudine is a nucleoside analog of the unnatural beta-L configuration which has potent antiviral activity against hepatitis B virus (HBV). Clevudine is expected to have similar pattern of resistance profile as lamivudine. However, there was no report on the mutation associated with clevudine resistance in patients with chronic hepatitis B. We report a case of young male patient with chronic hepatitis B who presented with clevudine resistance. The patient had received lamivudine therapy for 5 months with reduced serum HBV DNA levels. Then, lamivudine was switched to clevudine monotherapy. After the 6 months of clevudine therapy, the patient developed virologic breakthrough (>1.0x10(8) copies/mL) as well as biochemical breakthrough, which was associated with the presence of rtM204I plus rtL80I mutant. After switching from clevudine to adefovir, the viral load decreased with biochemical improvement.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antivirais
/
Arabinofuranosiluracila
/
Ácidos Fosforosos
/
DNA Viral
/
Sequência de Bases
/
Adenina
/
Inibidores da Transcriptase Reversa
/
Lamivudina
/
Hepatite B Crônica
/
Substituição de Aminoácidos
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
The Korean Journal of Gastroenterology
Ano de publicação:
2008
Tipo de documento:
Artigo
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