Changes of Blood Sugar Levels by Infusion of Elitol, D5 / W and D5 / LR / 대한마취과학회지

ABSTRACT

Rapid administration of solution containing dextrose results in marked hyperglycemia and osmotic diuresis. Jeon reported blood sugar of 200 to 465mg per 100ml. in patients receiving 10ml per hour of 5% dextrose in 1/3 saline and the urine output went up to 340ml per hour. This study was undertatken to evaluate Elitol asto changes of blood sugar concentrations when it was administered rapidly. Elitol is a maltose contained in a balanced salt solution shich has a different effect in the blood sugar level from a gulcose contained solution. 40 patients were chosen at random and divided into 3 groups i.e. one group 5% dextrose in water(D5/W), the second group 5% dextrose in lactated ringer's solution(D5/LR) and the third group the Elitol solution. Patient's blood was drawn on the operating table prior to starting I.V. infusion for the measurement of blood sugar in various conditions of N.P.O. Intravenous fluid was administered at 10ml/kg/hour while anesthesia was induced and maintained with an endotracheal tube in place. The blood samples were taken after one hour, 2 hours and 3 hours from the time the LV. infusion started. In the group of 5% dextrose in water, the value of blood sugar was 82+/-mg% at NPO2 205+/-36mg% at 1 hour, 273+/-49mg% at 2 hours, and 316+/-63mg% at 3 hours. The blood sugar values increased markedly. In the group of 5% dextrose in lactate Ringer's solution the values of blood sugar were 99+/-16mg% at NPO, 255+/-49mg% at 1 hour, 285+/-54mg% at 2 hours and 292+/-78mg% at 3hours. The values of blood sugar increased significantly and were very similar to the 1st group. In the group of Elitol, the values of blood sugar were 92+/-12mg% at NPO, 126+/-21mg% at 1 hour, 131+/-24mg% at 2 hours and 128+/-23mg% at 3hours. The increase of blood sugar levels were insignificant which is entirely different from the change of blood sugar in the above groups. Accordingly we came to the conclusion that rapid infusion of Elitol solution affects the blood sugar levels insignificantly compared to the dextrose containing solutions which increase the blood sugar levels greatly.