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Blood flow-improving activity of methyl jasmonate-treated adventitious roots of mountain ginseng / 한국실험동물학회지
Laboratory Animal Research ; : 105-113, 2017.
Artigo em Inglês | WPRIM | ID: wpr-204555
ABSTRACT
Ginsenosides from Panax ginseng are well known for their diverse pharmacological effects including antithrombotic activity. Since adventitious roots of mountain ginseng (ARMG) also contain various ginsenosides, blood flow-improving effects of the dried powder and extract of ARMG were investigated. Rats were orally administered with dried powder (PARMG) or ethanol extract (EARMG) of ARMG (125, 250 or 500 mg/kg) or aspirin (30 mg/kg, a reference control) for 3 weeks. Forty min after the final administration, carotid arterial thrombosis was induced by applying a 70% FeCl₃-soaked filter paper outside the arterial wall for 5 min, and the blood flow was monitored with a laser Doppler probe. Both PARMG and EARMG delayed the FeCl₃-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at high doses. In mechanism studies, a high concentration of EARMG inhibited platelet aggregation induced by collagen in vitro. In addition, EARMG improved the blood lipid profiles, decreasing triglyceride and cholesterol levels. Although additional action mechanisms remain to be clarified, it is suggested that ARMG containing high amount of ginsenosides such as Rg₃ improves blood flow not only by inhibiting oxidative thrombosis, but also by modifying blood lipid profiles.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Trombose / Triglicerídeos / Técnicas In Vitro / Agregação Plaquetária / Aspirina / Colesterol / Colágeno / Ginsenosídeos / Etanol / Panax Limite: Animais Idioma: Inglês Revista: Laboratory Animal Research Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Trombose / Triglicerídeos / Técnicas In Vitro / Agregação Plaquetária / Aspirina / Colesterol / Colágeno / Ginsenosídeos / Etanol / Panax Limite: Animais Idioma: Inglês Revista: Laboratory Animal Research Ano de publicação: 2017 Tipo de documento: Artigo