Studies on familial of basophil histamine releasability / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
;
: 628-639, 1998.
Artigo
em Coreano
| WPRIM
| ID: wpr-204960
ABSTRACT
BACKGROUND:
Bronchial asthma is a complex genetic disorder. Although serum IgE level and bronchial hyperresponsiveness are well known to be under genetic control, the influence of genetic factors on basophil releasability has been seldom studied.OBJECTIVE:
The present study was carried out to investigate whether genetic factors may influence the basophil histamine releasability. MATERIALS ANDMETHODS:
We studied 50 children, 32 with atopic asthma (AA) and 18 normal control (NC), and their parents. Suspensions of leukocytes were isolated and stimulated with Ca ionophore and anti-IgE antibody. Then, histamine in the supernatant was as-sayed by an automated fluorometric analyzer.RESULTS:
Among the probands, AA children had a significantly higher anti-IgE induced histamine release than NC children. In contrast, Ca ionophore-induced histamine release was similar between the two groups. Ca ionophore-induced or anti-IgE-induced histamine release was not significantly different between parents of AA children and those of NC children. However, the maximal histamine release by Ca ionophore in parents had a significant correlation with that of probands, whereas the values by anti-IgE were not correlated between probands and their parents.CONCLUSION:
We confirmed that basophils from patients with atopic asthma are characterized by a specific increase in IgE-mediated histamine release. The significant correlation of Ca ionophore-induced maximal histamine release between children and their parents suggests that genetic factors may play an important role in the control of non-IgE-mediated relessability from basophils.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pais
/
Asma
/
Suspensões
/
Basófilos
/
Imunoglobulina E
/
Histamina
/
Genética
/
Liberação de Histamina
/
Leucócitos
Limite:
Criança
/
Humanos
Idioma:
Coreano
Revista:
Journal of Asthma, Allergy and Clinical Immunology
Ano de publicação:
1998
Tipo de documento:
Artigo
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