The Relationship between Mitochondria and NLRP3 Inflammasome
International Journal of Oral Biology
;
: 85-90, 2017.
Artigo
em Coreano
| WPRIM
| ID: wpr-205041
ABSTRACT
Mitochondria participate in various intracellular metabolic pathways such as generating intracellular ATP, synthesizing several essential molecules, regulating calcium homeostasis, and producing the cell's reactive oxygen species (ROS). Emerging studies have demonstrated newly discovered roles of mitochondria, which participate in the regulation of innate immune responses by modulating NLRP3 inflammasomes. Here, we review the recently proposed pathways to be involved in mitochondria-mediated regulation of inflammasome activation and inflammation 1) mitochondrial ROS, 2) calcium mobilization, 3) nicotinamide adenine dinucleotide (NAD+) reduction, 4) cardiolipin, 5) mitofusin, 6) mitochondrial DNA, 7) mitochondrial antiviral signaling protein. Furthermore, we highlight the significance of mitophagy as a negative regulator of mitochondrial damage and NLRP3 inflammasome activation, as potentially helpful therapeutic approaches which could potentially address uncontrolled inflammation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
DNA Mitocondrial
/
Cardiolipinas
/
Trifosfato de Adenosina
/
Cálcio
/
Espécies Reativas de Oxigênio
/
Redes e Vias Metabólicas
/
Inflamassomos
/
Mitofagia
/
Homeostase
/
Imunidade Inata
Idioma:
Coreano
Revista:
International Journal of Oral Biology
Ano de publicação:
2017
Tipo de documento:
Artigo
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