Epidemiologic Study in 428 Cases of Cleft Lip and Palate in Koreans: A Prospective Study

ABSTRACT

This prospective study was carried out to provide an clinical data on congenital cleft lip and/or palate. With the data obtained from formal cleft lip and cleft palate sheets taken at the time of admission of 428 patients who had been admitted to Chungnam National University Hospital (December, 1983-October, 1996) and Asan Medical Center(November, 1996-July, 2000), the epidemiological data and influencing factors were studied. The results were as follows, 1.A distribution according to types of cleft were cleft lip alone in 23%, cleft lip with cleft palate in 37% and isolated cleft palate in 40%. 2.For types in cleft lip, the ratio of left side right side bilateral was 3.4 1.8 1.0 3.The ratio of complete type incomplete type was 0.8 1.0 4.The rate of positive prenatal medication history during the first trimester of pregnancy was 39.9% of total patients 5.The percentage of positive family history was 9.3% of total patients 6.The rate of association with other congenital anomalies was 19.7% 7.The social class was not an definitive contributing factor according to monthly income comparison. The authors believe that this prospective study produced more accurate and reliable data in the assessment of the rates in positive family history and congenital anomalies than restropective ones.