Interaction between Causative Factors of Cervical Cancer and BARD-1 (BRCA-associated ring domain-1) Polymorphism / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
; : 1698-1707, 2005.
Article
em Ko
| WPRIM
| ID: wpr-205143
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: The aim of this study was to identify interaction between causative factors of cervical cancer and BARD-1 (BRCA1 associated ring domain-1) polymorphism on cervical carcinogenesis in Korean women. METHODS: We evaluated 1,347 patients composed of women who had cervical cancer (n=337) and cervical intraepithelial neoplasia (n=308) and normal control healthy women (n=702) from October 2000 until November 2001. The single nucleotide polymorphisms (SNPs) of BARD-1 were evaluated from extracted DNA of peripheral blood with automatic DNA sequencer. The difference of each SNP between normal controls and patients was evaluated in the adjusted environmental background. RESULTS: In environmental aspect, the cervical cancer increased in the women who had the lower level of education, smoking history, the younger age of the first sexual intercourse, and the more child-bearing . The women who had BARD V507M (Arg/Arg) showed 1.6 fold increased risk in cervical cancer than the women who had BARD V507M (G/G), (G/A)(p=0.0433). And the risk increased with BARD R378S (C/C) among who have environmental risk factors compared with BARD R378S (G/G), (G/C) allele positive who have no environmental risk factors. CONCLUSION: We found that the level of education, the age at first intercourse, and the number of children were the independent risk factors in cervical carcinogenesis. The specific combination of BARD-1 and gene-environmental interactions were significantly noted in the cervical carcinogenesis in Korean women.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Fumaça
/
DNA
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Fumar
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Displasia do Colo do Útero
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Neoplasias do Colo do Útero
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Fatores de Risco
/
Coito
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Polimorfismo de Nucleotídeo Único
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Educação
/
Alelos
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Female
/
Humans
Idioma:
Ko
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2005
Tipo de documento:
Article