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The Expression of alpha2-Adrenergic Receptor Subtypes in the Central Nervous System of Peripheral Nerve Injured Rats / 대한마취과학회지
Korean Journal of Anesthesiology ; : 468-475, 2006.
Artigo em Coreano | WPRIM | ID: wpr-205605
ABSTRACT

BACKGROUND:

The change of expression of the alpha2-adrenergic receptor (alpha(2)-AR) subtypes in the thalamus and hypothalamus were investigated in a neuropathic pain rat model.

METHODS:

The left sciatic nerve was clamped for creating a neuropathic pain model in five rats. A sham operation was done in three rats as control group. Behavioral tests for pain were conducted by using mechanical stimuli applied to the hind paws. After 7 days, the expression of alpha(2)-AR subtype mRNA in the rat thalamus and hypothalamus was measured using real time polymerase chain reaction.

RESULTS:

Mechanical allodynia were developed on postoperative 1, 3, and 7 days in the neuropathic pain model. The expression of alpha(2A)-AR, alpha(2B)-AR, and alpha(2C)-AR was significantly higher in the thalamus and hypothalamus in the neuropathic pain model (P > 0.05).

CONCLUSIONS:

These results would suggest that the subtypes of alpha(2)-AR in thalamus and hypothalamus may contribute to produce neuropathic pain.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Nervos Periféricos / Nervo Isquiático / Tálamo / RNA Mensageiro / Sistema Nervoso Central / Modelos Animais / Traumatismos dos Nervos Periféricos / Reação em Cadeia da Polimerase em Tempo Real / Hiperalgesia / Hipotálamo Limite: Animais Idioma: Coreano Revista: Korean Journal of Anesthesiology Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Nervos Periféricos / Nervo Isquiático / Tálamo / RNA Mensageiro / Sistema Nervoso Central / Modelos Animais / Traumatismos dos Nervos Periféricos / Reação em Cadeia da Polimerase em Tempo Real / Hiperalgesia / Hipotálamo Limite: Animais Idioma: Coreano Revista: Korean Journal of Anesthesiology Ano de publicação: 2006 Tipo de documento: Artigo