The Expression of alpha2-Adrenergic Receptor Subtypes in the Central Nervous System of Peripheral Nerve Injured Rats / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 468-475, 2006.
Artigo
em Coreano
| WPRIM
| ID: wpr-205605
ABSTRACT
BACKGROUND:
The change of expression of the alpha2-adrenergic receptor (alpha(2)-AR) subtypes in the thalamus and hypothalamus were investigated in a neuropathic pain rat model.METHODS:
The left sciatic nerve was clamped for creating a neuropathic pain model in five rats. A sham operation was done in three rats as control group. Behavioral tests for pain were conducted by using mechanical stimuli applied to the hind paws. After 7 days, the expression of alpha(2)-AR subtype mRNA in the rat thalamus and hypothalamus was measured using real time polymerase chain reaction.RESULTS:
Mechanical allodynia were developed on postoperative 1, 3, and 7 days in the neuropathic pain model. The expression of alpha(2A)-AR, alpha(2B)-AR, and alpha(2C)-AR was significantly higher in the thalamus and hypothalamus in the neuropathic pain model (P > 0.05).CONCLUSIONS:
These results would suggest that the subtypes of alpha(2)-AR in thalamus and hypothalamus may contribute to produce neuropathic pain.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Nervos Periféricos
/
Nervo Isquiático
/
Tálamo
/
RNA Mensageiro
/
Sistema Nervoso Central
/
Modelos Animais
/
Traumatismos dos Nervos Periféricos
/
Reação em Cadeia da Polimerase em Tempo Real
/
Hiperalgesia
/
Hipotálamo
Limite:
Animais
Idioma:
Coreano
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2006
Tipo de documento:
Artigo
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