Is Arterial Stiffness Useful in Differentiating Patients with Coronary Artery Disease from Risk Factor Only Patients?
Korean Circulation Journal
;
: 845-855, 2004.
Artigo
em Coreano
| WPRIM
| ID: wpr-205841
ABSTRACT
BACKGROUND AND OBJECTIVE:
The endothelial function, carotid intima-media thickness (CIMT) and arterial stiffness are known as surrogates of atherosclerosis, but it is not clear whether these surrogates can discriminate patients with coronary artery disease (CAD) from those with risk factor. The intention was to compare these 3 surrogates in patients with CAD and those with risk factor only. SUCJECTS ANDMETHODS:
Forty-three patients with CAD (mean age58, 32 men), 18 age and sex matched healthy people (mean age52, 9 men) and 16 patients (mean age53, 12 men) with atherosclerosis risk factor only were enrolled. The endothelial function (flow-mediated brachial artery dilation, FMD) and CIMT were measured by high-resolution ultrasound and the arterial stiffness by an oscillometric method.RESULTS:
There was a significant difference between the CAD and risk factor groups (3.46+/-1.3% vs. 5.77+/-2.54%, p0.05) in the measured FMD. The CIMT showed a significant difference between the CAD and healthy groups (0.89+/-0.14 mm vs. 0.78+/-0.07 mm, p0.05). There were significant differences among all groups in relation to the arterial stiffness (CAD group1524+/-289 cm/sec, risk group1342+/-202 cm/sec, healthy group1195+/-119 cm/sec, p<0.05). The arterial stiffness showed significant correlation with the FMD (r=-0.322, p=0.005) and CIMT (r=0.310, p=0.007).CONCLUSION:
Of the 3 surrogates, the arterial stiffness measurement showed the best reliability in differentiating the CAD from the risk factor only groups as well as from healthy subjects. This study suggests the arterial stiffness can be used as a novel noninvasive test for early diagnosis of CAD in patients at high risk of atherosclerosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Artérias
/
Doença da Artéria Coronariana
/
Artéria Braquial
/
Fatores de Risco
/
Ultrassonografia
/
Vasos Coronários
/
Intenção
/
Diagnóstico Precoce
/
Endotélio
/
Aterosclerose
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Fatores de risco
/
Estudo de rastreamento
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Circulation Journal
Ano de publicação:
2004
Tipo de documento:
Artigo
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