Severe Hepatic Sinusoidal Obstruction Syndrome in a Child Receiving Vincristine, Actinomycin-D, and Cyclophosphamide for Rhabdomyosarcoma: Successful Treatment with Defibrotide / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 1443-1447, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-205891
ABSTRACT
Hepatic sinusoidal obstruction syndrome (SOS) is a life-threatening syndrome that generally occurs as a complication after hematopoietic stem cell transplantation or, less commonly, after conventional chemotherapy. Regarding SOS in rhabdomyosarcoma patients who received conventional chemotherapy, the doses of chemotherapeutic agents are associated with the development of SOS. Several cases of SOS in rhabdomyosarcoma patients after receiving chemotherapy with escalated doses of cyclophosphamide have been reported. Here, we report on a 9-year-old female with rhabdomyosarcoma who developed severe SOS after receiving chemotherapy consisting of vincristine, actinomycin-D, and a moderate dose of cyclophosphamide. She was treated successfully with defibrotide without sequelae to the liver.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Rabdomiossarcoma
/
Vincristina
/
Hepatopatia Veno-Oclusiva
/
Transplante de Células-Tronco Hematopoéticas
/
Ciclofosfamida
/
Tratamento Farmacológico
/
Fígado
Limite:
Criança
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Cancer Research and Treatment
Ano de publicação:
2016
Tipo de documento:
Artigo
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