Pharmacological Prevention of Post-Anesthetic Shivering: Clonidine Vs Meperidine: A Meta-Analysis of Randomized-Controlled Trials / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 63-72, 1999.
Artigo
em Coreano
| WPRIM
| ID: wpr-206013
ABSTRACT
BACKGROUND:
Post-operative shivering is one of the potential complications for any surgical patient. Its incidence varies from 5% to 65%, and many preventive and treatment modalities have been reported. For the effective prevention of post-anesthetic shivering by using intravenous clonidine or meperidine, randomized controlled studies were reviewed. The overall incidence of shivering after clonidine or meperidine administration, and the anti-shivering effect of clonidine and meperidine were evaluated.METHODS:
DATA SOURCES Medline search from 1978 to March 1998. DATA SELECTION We selected studies that had investigated the preventive anti-shivering effect of intravenous clonidine or meperidine by randomized controlled trials. Ten clinical trials were evaluated.RESULTS:
The pooled odd ratio of the patients who received clonidine was 0.32 (95% confidence interval, 0.22~0.47) and it seemed to be effective. But these studies showed little evidence of significant homogeneity (P=0.01). In the subgroup analysis, the pooled odd ratio of group A (early administration or intra-operative infusion group) was 0.47 (95% CI 0.31~0.72) evidenced effectiveness but failed to prove homogeneity (P=0.047). But group B (the late intra-operative administration group) had a pooled odd ratio of 0.10 (95% CI 0.05~0.22) and showed homogeneity (P=0.98). In meperidine trials, the pooled odd ratio was 0.20 (95% CI 0.07~0.55).CONCLUSION:
We present quantitative evidence based on a meta-analysis of pooled effect size from randomized trials that clonidine is more beneficial for the prevention of post-anesthetic shivering and more effective than meperidine when it is administrated during later period of surgery.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Estremecimento
/
Incidência
/
Armazenamento e Recuperação da Informação
/
Clonidina
/
Meperidina
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo de incidência
/
Estudo prognóstico
/
Revisões Sistemáticas Avaliadas
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
1999
Tipo de documento:
Artigo
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