Early Pathologic Changes of Kidney after Intraperitoneal Challenge with Sodium Oxalate in Rat / 대한비뇨기과학회지

ABSTRACT

To investigate the relationship between calcium oxalate stone formation and pathological change of the rat kidney, the early phases of calcium oxalate crystal formation in rat kidneys after intraperitoneal challenge with sodium oxalate were examined at various time interval. The number, size and distribution of the calcium oxalate particles, which were formed intraluminally in proximal tubule, depend on the pathological change according to the time interval after its injection. Tubular obstruction and dilatation due to cellular edema followed by necrosis of tubules and interstitial inflammation were related with increase in number and size of the calcium oxalate particles.