Cost-Effectiveness of Recombinant Tissue Plasminogen Activator in the Management of Acute Ischemic Stroke: A Systematic Review
Journal of Clinical Neurology
;
: 117-126, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-207098
ABSTRACT
BACKGROUND AND PURPOSE:
This work was undertaken to review the current cost-effectiveness analysis data on thrombolysis by intravenous (IV) therapy with recombinant tissue plasminogen activator (rtPA) for acute ischemic stroke.METHODS:
PubMed was searched for articles published between 1995 and 2008. The cost-effectiveness analysis data from eight eligible studies were reviewed, paying particular attention to their modeling assumptions and the quality of the source data.RESULTS:
The reviewed studies were from six countries USA (n=2), UK (n=2), Canada (n=1), Australia (n=1), Spain (n=1), and Denmark (n=1); most were performed from the healthcare-system and/or societal perspectives. IV rtPA was associated with an acceptable increase in short-term cost [range US$ 36-236/patient; US$ 29,148-55,591/quality-adjusted life-years (QALYs)], and a net long-term cost saving that was higher from a societal perspective (range -US$ 12,043 to -US$ 630/patient; -US$ 207,253 to -US$ 21,938/QALYs) than from a healthcare-system perspective (range -US$ 5,811 to -US$ 5,415/patient; -US$ 41,137 to -US$ 4,662/QALYs).CONCLUSIONS:
IV rtPA seems to be a cost-effective strategy for the management of acute ischemic stroke, and might reduce the associated healthcare costs as well as patients' disabilities. Further cost-effectiveness research and the development of a public health strategy are warranted to optimize the use of rtPA in Korea.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Austrália
/
Espanha
/
Canadá
/
Saúde Pública
/
Custos de Cuidados de Saúde
/
Redução de Custos
/
Ativador de Plasminogênio Tecidual
/
Acidente Vascular Cerebral
/
Dinamarca
/
Coreia (Geográfico)
Tipo de estudo:
Avaliação Econômica em Saúde
/
Estudo prognóstico
/
Revisões Sistemáticas Avaliadas
País/Região como assunto:
América do Norte
/
Ásia
/
Europa
/
Oceania
Idioma:
Inglês
Revista:
Journal of Clinical Neurology
Ano de publicação:
2010
Tipo de documento:
Artigo
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