Correlation of Serum Vascular Endothelial Growth Factor and Matrix Metalloproteinase-2 in Patients Complicated with Preeclampsia and Normotensive Pregnant Women / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 29-35, 2005.
Artigo
em Coreano
| WPRIM
| ID: wpr-207198
ABSTRACT
OBJECTIVE:
The aim of this study is to evaluate whether serum levels of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) are different between normotensive pregnant women and preeclampsia patients and also to investigate the relationship of VEGF and MMP-2.METHODS:
We analyzed the serum levels of VEGF and MMP-2 in patients with preeclampsia (n=20) and normotensive pregnant women (n=20).RESULTS:
Of the normotensive pregnant and preeclampsia women, the serum VEGF levels are 0.28 +/- 0.14 ng/mL 2.39 +/- 0.75 ng/mL, the serum MMP-2 levels are 11.81 +/- 1.75 ng/mL, 31.99 +/- 6.5 ng/mL respectively. These serum levels are higher in preeclampsia patients than normotensive pregnant women (P<0.001) The serum VEGF levels positively relate with plasma MMP-2 levels in preeclampsia (P<0.05, r=0.78).CONCLUSION:
The serum VEGF levels highly correlate with the increased MMP-2 levels in preeclampsia, which may contribute the pathophysiology of preeclampsia.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Pré-Eclâmpsia
/
Metaloproteinase 2 da Matriz
/
Gestantes
/
Fator A de Crescimento do Endotélio Vascular
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2005
Tipo de documento:
Artigo
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