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Anti-Melanogenic Potentials of Nanoparticles from Calli of Resveratrol-Enriched Rice against UVB-Induced Hyperpigmentation in Guinea Pig Skin
Biomolecules & Therapeutics ; : 85-93, 2016.
Artigo em Inglês | WPRIM | ID: wpr-20734
ABSTRACT
We already reported that genetically engineered resveratrol-enriched rice (RR) showed to down-regulate skin melanogenesis. To be developed to increase the bioactivity of RR using calli from plants, RR was adopted for mass production using plant tissue culture technologies. In addition, high-pressure homogenization (HPH) was used to increase the biocompatibility and penetration of the calli from RR into the skin. We aimed to develop anti-melanogenic agents incorporating calli of RR (cRR) and nanoparticles by high-pressure homogenization, examining the synergistic effects on the inhibition of UVB-induced hyperpigmentation. Depigmentation was observed following topical application of micro-cRR, nano-calli of normal rice (cNR), and nano-cRR to ultraviolet B (UVB)-stimulated hyperpigmented guinea pig dorsal skin. Colorimetric analysis, tyrosinase immunostaining, and Fontana-Masson staining for UVB-promoted melanin were performed. Nano-cRR inhibited changes in the melanin color index caused by UVB-promoted hyperpigmentation, and demonstrated stronger anti-melanogenic potential than micro-cRR. In epidermal skin, nano-cRR repressed UVB-promoted melanin granules, thereby suppressing hyperpigmentation. The UVB-enhanced, highly expressed tyrosinase in the basal layer of the epidermis was inhibited by nano-cRR more prominently than by micro-cRR and nano-cNR. The anti-melanogenic potency of nano-cRR also depended on pH and particle size. Nano-cRR shows promising potential to regulate skin pigmentation following UVB exposure.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Tamanho da Partícula / Plantas / Pele / Pigmentação da Pele / Guiné / Monofenol Mono-Oxigenase / Hiperpigmentação / Epiderme / Nanopartículas / Cobaias Limite: Animais País/Região como assunto: África Idioma: Inglês Revista: Biomolecules & Therapeutics Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Tamanho da Partícula / Plantas / Pele / Pigmentação da Pele / Guiné / Monofenol Mono-Oxigenase / Hiperpigmentação / Epiderme / Nanopartículas / Cobaias Limite: Animais País/Região como assunto: África Idioma: Inglês Revista: Biomolecules & Therapeutics Ano de publicação: 2016 Tipo de documento: Artigo