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Effect of Type 2 Diabetes Mellitus on Prognosis of Nonmetastatic Renal Cell Cancer
Korean Journal of Urology ; : 499-503, 2013.
Artigo em Inglês | WPRIM | ID: wpr-207553
ABSTRACT

PURPOSE:

We evaluated the prognostic value of type 2 diabetes mellitus (DM) in patients treated surgically for localized renal cell carcinoma (RCC). MATERIALS AND

METHODS:

Between 1995 and 2011, 588 patients with renal tumor diagnoses were treated surgically and 492 patients with pathologically confirmed nonmetastatic RCC diagnoses were included in the study. The associations of clinical and pathologic parameters with a type 2 DM diagnosis were evaluated. Kaplan-Meier estimations for disease-specific survival (DSS) and overall survival (OS) were generated according to type 2 DM diagnosis, and the log-rank test was used to compare survival according to the variables.

RESULTS:

The mean age of the patients was 56.7+/-12 years (range, 15 to 84 years; median, 58 years) and the mean length of follow-up was 35.9+/-28 months (range, 1 to 145 months; median, 34.3 months). Of the 492 patients, 62 (12.6%) had a diagnosis of DM at the time of surgery (group I) and 430 did not have DM (group II). The mean age and the incidence of clear cell RCC histological subtype were significantly higher in group I than in group II (p<0.001 and p=0.036, respectively). Although DSS and OS were lower in group I, this difference was not significant. Type 2 DM was not detected as an independent prognostic factor for DSS and OS.

CONCLUSIONS:

This study investigated the role and effect of DM on the prognosis of localized RCC that was treated surgically. The present study did not detect DM as an independent prognostic factor for RCC.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prognóstico / Carcinoma de Células Renais / Incidência / Seguimentos / Diabetes Mellitus Tipo 2 Tipo de estudo: Estudo de incidência / Estudo observacional / Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Korean Journal of Urology Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prognóstico / Carcinoma de Células Renais / Incidência / Seguimentos / Diabetes Mellitus Tipo 2 Tipo de estudo: Estudo de incidência / Estudo observacional / Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Korean Journal of Urology Ano de publicação: 2013 Tipo de documento: Artigo