Acute Kidney Injury after Using Contrast during Cardiac Catheterization in Children with Heart Disease
Journal of Korean Medical Science
;
: 1102-1107, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-208221
ABSTRACT
Acute kidney injury (AKI) is closely associated with the mortality of hospitalized patients and long-term development of chronic kidney disease, especially in children. The purpose of our study was to assess the evidence of contrast-induced AKI after cardiac catheterization in children with heart disease and evaluate the clinical usefulness of candidate biomarkers in AKI. A total of 26 children undergoing cardiac catheterization due to various heart diseases were selected and urine and blood samples were taken at 0 hr, 6 hr, 24 hr, and 48 hr after cardiac catheterization. Until 48 hr after cardiac catheterization, there was no significant increase in serum creatinine level in all patients. Unlike urine kidney injury molecule-1, IL-18 and neutrophil gelatinase-associated lipocalin, urine liver-type fatty acid-binding protein (L-FABP) level showed biphasic pattern and the significant difference in the levels of urine L-FABP between 24 and 48 hr. We suggest that urine L-FABP can be one of the useful biomarkers to detect subclinical AKI developed by the contrast before cardiac surgery.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Iohexol
/
Cateterismo Cardíaco
/
Biomarcadores
/
Radiografia Intervencionista
/
Reprodutibilidade dos Testes
/
Sensibilidade e Especificidade
/
Meios de Contraste
/
Proteínas de Ligação a Ácido Graxo
/
Injúria Renal Aguda
/
Cardiopatias Congênitas
Tipo de estudo:
Estudo diagnóstico
Limite:
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
2014
Tipo de documento:
Artigo
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