Comparison of palonosetron with ondansetron in preventing postoperative nausea and vomiting after thyroidectomy during a 48-hour period
Anesthesia and Pain Medicine
;
: 312-316, 2012.
Artigo
em Coreano
| WPRIM
| ID: wpr-208517
ABSTRACT
BACKGROUND:
Postoperative nausea and vomiting (PONV) are common complications after general anesthesia. This study compared the effects of palonosetron and ondansetron in preventing PONV in patients undergoing thyroidectomy.METHODS:
100 non-smoking female subjects were randomly assigned to a palonosetron group (n = 50) or an ondansetron group (n = 50). The patients of each group received 0.075 mg of palonosetron or 8 mg of ondansetron through intravenous bolus injection before induction of general anesthesia. The incidence of nausea and vomiting were monitored at 2 h, 24 h and 48 h after operation.RESULTS:
The incidence of PONV during 48 h after operation had no significant differences between the groups. However, the incidence of nausea was lower in the palonosetron group than in the ondansetron group (34% vs. 56%, P = 0.027). No differences were observed in incidences of vomiting, use of antiemetics and adverse events between the groups.CONCLUSIONS:
Palonosetron was more effective than ondansetron in preventing nausea for patients undergoing thyroidectomy. However, the effect of palonosetron or ondansetron in preventing PONV was similar.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Quinuclidinas
/
Tireoidectomia
/
Vômito
/
Incidência
/
Ondansetron
/
Náusea e Vômito Pós-Operatórios
/
Isoquinolinas
/
Anestesia Geral
/
Antieméticos
/
Náusea
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Anesthesia and Pain Medicine
Ano de publicação:
2012
Tipo de documento:
Artigo
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