Effect of Intracerebroventricular Digitalis on Cardiovascular System of Rabbits
Journal of Korean Neurosurgical Society
; : 235-244, 1989.
Article
em Ko
| WPRIM
| ID: wpr-208585
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WPRO
ABSTRACT
Influences of intracerebroventricular(icv) ouabain on cardiovascular system and on pressor response to raised intracranial pressure(ICP) were investigated in urethane-anesthetized rabbits. Intravenous(iv) 40 microgram/kg ouabain did not affect blood pressure of rabbit. Icv ouabain(5, 10, 20 microgram/kg) and digoxin(6.25, 12.5 microgram/kg) produced dose-dependent pressor responses and marked decrease of heart rate. After bilateral vagotomy, the bradycardiac effect of ouabain disappeared, while the pressor effect was significantly potentiated. The ouabain-induced pressor effect was not affected by iv and icy phentolamine or propranolol, and significantly inhibited by icy infusion of lidocaine(0.1 mg/kg/min) and diazepam(0.025 mg/kg/min). The pressor response to raised ICP was not affected by iv 40 microgram/kg ouabain but disappeared by icy 10 microgram/kg ouabain and 6.25 microgram/kg digoxin. These data suggests that ouabain causes pressor effect through direct interaction with a site(s) in central nervous system and bradycardiac effect by direct activation of vagal center, and ouabain blocks central sympathetic stimulation by increase of ICP in rabbits.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Ouabaína
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Fentolamina
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Propranolol
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Vagotomia
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Pressão Sanguínea
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Sistema Cardiovascular
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Pressão Intracraniana
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Sistema Nervoso Central
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Digitalis
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Digoxina
Limite:
Animals
Idioma:
Ko
Revista:
Journal of Korean Neurosurgical Society
Ano de publicação:
1989
Tipo de documento:
Article